COMPOSITION

Ceftazidime 2gm and Avibactam 0.5gm  Injection

MODE OF ACTION

Ceftazidime is bactericidal and has the same mode of action as other beta -lactam antibiotics (such as penicillins). Ceftazidime disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity. Avibactam inhibits beta lactamases. The combination of Avibactam and Ceftazidime is active against all the organisms sensitive to Ceftazidime. In addition, it demonstrates synergistic activity (reduction in MICs for the combination versus those of each component) in a variety of organisms.

INDICATIONS

• Complicated Intra-abdominal Infections (cIAIs)
• Complicated Urinary Tract Infection (cUTI) including Pyelonephritis
• Hospital-acquired Bacterial Pneumonia (HABP)
• Ventilator-associated Bacterial Pneumonia (VABP)

DOSAGE

1.Complicated Intra-Abdominal Infections

AVILITE  2.5 gm grams (ceftazidime 2 grams and avibactam 0.5 grams) intravenously every 8 hours plus metronidazole (0.5 grams intravenously every 8 hours)

2.Complicated Urinary Tract Infections, Including Pyelonephritis

AVILITE  2.5 gm (ceftazidime 2 gms and avibactam 0.5 grams) intravenously every 8 hours intravenously every 8 hours for 10 to 14 days of total therapy.

3.Hospital-Acquired Bacterial Pneumonia And Ventilator-Associated Bacterial Pneumonia

AVILITE  2.5 gm (ceftazidime 2 grams and avibactam 0.5 grams) intravenously every 8 hours intravenously every 8 hours for 7 to 14 days of therapy.